The number of mouse cDNAs identified greatly exceeds the number of genes predicted from the sequenced human and mouse genomes. The largest transcriptome reported so far comprises 60,770 mouse fulllength cDNA clones, and is an effective reference data set for comparative transcriptomics. In this review, we discuss aspects of the transcriptome of various organisms in relation to the mouse data, in order to shed light on the regulatory mechanisms and physiological significance of these abundant RNAs.. The ncRNAs function in range of regulatory mechanisms for gene expression and other biological processes.

The ncRNAs function in range of regulatory mechanisms for gene expression and other biological processes. This is largely because of extensive alternative splicing and the presence of many noncoding RNAs ncRNAs, which are difficult to predict from genomic sequences. They might also have contributed to the increased functional diversification of genomes during evolution. Notably, ncRNAs are major component of the transcriptomes of higher organisms, and many senseantisense pairs have been identified. The largest transcriptome reported so far comprises 60,770 mouse fulllength cDNA clones, and is an effective reference data set for comparative transcriptomics.
Tags: evolution, genomes, transcriptomics